Topiramate for Abnormal Eating Behaviour in Frontotemporal Dementia
نویسندگان
چکیده
Topiramate is a sulfamate-substituted monosaccharide anticonvulsant that is associated with anorexia and weight loss and has been used to treat binge eating disorder and bulimia nervosa. This report describes a man with frontotemporal dementia, behavioural variant, associated with abnormal eating behaviour which appeared to respond to topiramate. We review the physiological basis of abnormal eating behaviour in frontotemporal dementia and explore possible mechanisms of action by which topiramate may modify eating behaviour in this condition.
منابع مشابه
Distinct behavioural profiles in frontotemporal dementia and semantic dementia.
OBJECTIVE To test predictions that frontotemporal dementia and semantic dementia give rise to distinct patterns of behavioural change. METHODS An informant based semistructured behavioural interview, covering the domains of basic and social emotions, social and personal behaviour, sensory behaviour, eating and oral behaviour, repetitive behaviours, rituals, and compulsions, was administered t...
متن کاملChanges in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease.
BACKGROUND Despite numerous reports of changes in satiety, food preference, and eating habits in patients with frontotemporal dementia, there have been few systematic studies. OBJECTIVES To investigate the frequency of changes in eating behaviours and the sequence of development of eating behaviours in frontotemporal dementia and Alzheimer's disease, using a caregiver questionnaire. METHODS...
متن کاملPhenomenology and anatomy of abnormal behaviours in primary progressive aphasia
Primary progressive aphasia (PPA) is a group of disorders with progressive language impairment. Abnormal behaviour may develop in PPA as the disease evolves, but the clinical features and brain basis of behavioural change in PPA have not been fully defined. 33 PPA patients (9 semantic dementia, SD, 14 progressive nonfluent aphasia, PNFA, 7 logopenic/phonological aphasia, LPA and 3 patients with...
متن کاملFronto-striatal atrophy correlates of neuropsychiatric dysfunction in frontotemporal dementia (FTD) and Alzheimer's disease (AD)
Behavioural disturbances in frontotemporal dementia (FTD) are thought to reflect mainly atrophy of cortical regions. Recent studies suggest that subcortical brain regions, in particular the striatum, are also significantly affected and this pathology might play a role in the generation of behavioural symptoms. OBJECTIVE To investigate prefrontal cortical and striatal atrophy contributions to ...
متن کاملAssessment of Aphasia in Iranian Patients Suffering From Frontotemporal Dementia
Objective Frontotemporal dementia (FTD) is an uncommon type of dementia. The hallmark feature of FTD is the presentation with aphasia, or behavioral changes which are varies in different subtypes of the disease. We propose a quantitative aphasia test as an additive diagnostic tool for differentiation of FTD subtypes. Method: The study was performed on 20 patients, who were referred to dementia...
متن کامل